Purolite develops and manufactures resin beads used in the most regulated industries to separate, remove or recover very specific elements and compounds. Purolite produces more than 1,000 active commercial products.

Our healthcare and life science products provide innovative solutions for a range of applications, including chromatographic separation, diagnostics, nanoparticle milling, APIs and biocatalysis. These resins are solving critical challenges across global medical device, nutraceutical, and pharmaceutical industries. Our unmatched technical support, regulatory expertise and commitment to security of supply place Purolite resins at the forefront of the global Healthcare and Life Sciences marketplace.

Praesto® bioprocessing products aim to improve the accessibility and availability of cutting-edge antibody therapeutics worldwide, which are typically used to treat, extend life and improve quality of life for patients with cancer, arthritis, diabetes and many other conditions. These agarose-based chromatographic resins are key raw materials for the downstream processing of antibodies and recombinant proteins, and are trusted by many of the leading biopharmaceutical manufacturers and CMOs. With hand-in-hand applications support and patented manufacturing technology, Praesto resins are currently implemented in FDA-approved commercial manufacturing processes and hundreds of clinical trials across the globe.

Presto® Jetted A50

Praesto Jetted A50 is a high performance agarose-based Protein A resin that delivers exceptional performance in terms of capacity, pressure flow and lifetime. Designed to meet the mAb processing demands of tomorrow, today, the combination of a highly cross-linked Praesto agarose base matrix with the NGL-ImpactTM A ligand from Repligen® provides increased capacity and excellent alkaline stability, reducing your bioburden risk and improving your process efficiencies from the same manufacturing footprint.

Praesto® Jetted A50 HipH

The unique properties of Praesto Jetted A50 HipH address challenges in eluting pH-sensitive mAbs and Fc-containing proteins, which can become unstable at pH levels typically used for elution with other Protein A resins (3 – 3.5). This resin provides alkaline stability, capacity of 60 g/L for polyclonal human IgG and elution up to pH 5.

This creates a wider operational window for your Protein A step, facilitating rapid process development and processing of all Fc-containing molecules by:

• • enabling use of a classic antibody purification platform
  • retaining the unique specificity of Protein A for high recovery and excellent productivity
  • minimizing impact on facility fit with comparable elution volumes and buffer usage
  • lowering levels of post-Protein A contaminants, reducing polishing challenges and driving process robustness