The NXT TFF System by PharmNXT Biotech is a highly efficient and automated system designed for ultrafiltration/diafiltration (UF/DF) processes. It offers a wide capacity range, from 20L to 500L, making it suitable for various batch volumes. With its compact design and low hold-up volume, it can accommodate cassettes with surface areas ranging from 0.5 to 2.5 m2. The system is known for its operational automation, enabling quick and easy flow kit changeouts and maximizing batch turnaround time. It combines hardware, a control system, and single-use flow kits to create a user-friendly and reliable system. The NXT TFF System is ideal for processing monoclonal antibodies, recombinant proteins, and vaccines, with single-use sensors providing comprehensive monitoring and process control capabilities.
Single-Use and Stainless Steel Tangential Flow Filteration System
The NXTtff system by PharmNXT is a system that’s perfect for running fully automated UF/DF processes at high capacity. It can handle any volume between 20L and 500L (200 g to 2.5 kg), and the compact system, has a low hold-up volume and the capacity to accommodate cassettes with surface area ranging from 0.5 to 2.5 m2
1) User-Friendly Software:
The control unit uses a simple, user-friendly interface via the touchscreen for data input and programming commands. The system is shielded from unauthorized access with password protection (four levels), and all events and actions (alarms, process steps, manual commands, etc.) are recorded in accordance with cGMP guidelines. The program allows you to operate the system manually or automatically.
2) Benefits:
The NXT TFF System by PharmNXT Biotech offers several advantages for TFF (ultrafiltration/diafiltration) applications:
- Designed with a focus on efficiency, ensuring optimal performance in TFF processes.
- Features a high level of operation-based automation, streamlining workflow and improving productivity.
- Enables quick and hassle-free change out of single-use flow kits, facilitating efficient batch turnaround.
- Offers easy cleanability, maintaining system hygiene and ensuring reliable and consistent results.
3) Various Applications:
Cell harvesting/clarification
- Recombinant protein concentration
- Vaccine concentration/purification
- Monoclonal antibody clarification/concentration
- Plasma purification/concentration
4) Integrated stainless steel tanks:
TFF processes require a tank to feed the filter and to collect retentate. If you’re running a tangential-flow filtration system, you need to consider your filtration tank. From mixing to measuring and from reducing recirculation volume to communicating with the rest of the system, the tank is an integral part of the filtration process. PharmNXT Biotech offers stainless steel tanks and single-use tanks as per process requirements. Different tank volumes can be chosen for specific systems, depending on the desired process volumes. A large range of options is available, including sensors, valves, mixers, pressurized tank, cooling jackets, and hoses
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NXTtff
The NXT TFF system by PharmNXT Biotech is a system that’s perfect for running fully automated UF/DF processes at high capacity. It can handle any volume between 20L and 500L (200 g to 2.5 kg), and the compact system, has a low hold-up volume and the capacity to accommodate cassettes with surface area ranging from 0.5 to 2.5 m2
Chromatography Resins (Purolite)
The purification of commercially-available monoclonal antibodies (mAbs) on the market today is typically performed in three chromatography steps. Purolite offer industry-leading solutions for each step.
Protein A Affinity Chromatography
A Protein A affinity resin is utilized as an initial antibody capture step. Praesto Protein A resins deliver exceptionally high purity (>99%) and yield in a single, efficient step.
Cation Exchange Chromatography
A Sulphopropyl- (SP) functionalized cation exchange resin in ‘bind and elute’ mode is used to remove aggregates and HCP (Host Cell Proteins).
Anion Exchange Chromatography
A Quarternary Amine (Q) functionalized anion exchange resin is used in ‘flow-through’ mode to remove trace contaminates and ensure sufficient viral clearance.
NXTmfilt
Single-use technology continues to be adopted for many areas of bioprocessing. The use of automation provides additional benefits in manufacturing such as consistency in product quality, reduced labor costs, and reduction of operator errors.